Fc-optimized antibodies quickly pull the trigger

Does clathrin pull the fission trigger?

C lathrin-mediated vesicle budding is essential for a variety of intracellular membrane transport reactions in the secretory and endocytic pathways (1, 2). This process can be dissected in several sequential steps that include the recruitment of the clathrin coat, membrane invagination and concomitant propagation of the clathrin lattice, constriction of the vesicle neck, and finally fission of ...

Clathrin-mediated endocytosis: membrane factors pull the trigger.

Clathrin-mediated endocytosis is a vesicular transport event involved in the internalization and recycling of receptors participating in signal transduction events and nutrient import as well as in the reformation of synaptic vesicles. Recent studies in vitro and in living cells have provided a number of new insights into the initial steps of clathrin-coated vesicle formation and the membrane f...

Difference Visualization to Pull the Trigger of Reflection

In this paper, we propose a framework for scaffolding conflict awareness to pull the trigger of reflection in a metacognitive process. If a learner only monitors his/her action or results of it, he/she may not reflect them. When a learner finds something strange, the learner is motivated to carry out the reflection. To feel its strangeness, the learner should know the normal situation. Then the...

IgM anti-Fc gamma R autoantibodies trigger neutrophil degranulation

Anti-Fc gamma R IgM monoclonal antibodies (mAbs) isolated from lipopolysaccharide-stimulated spleen cells from tightskin (TSK) mice were found to be polyspecific, reacting with a wide variety of molecules, including double-stranded DNA, topoisomerase, RNA polymerase, and different collagen types. Approximately 60% of the polyspecific IgM mAbs have anti-Fc gamma R specificity. These anti-Fc gamm...

Cytotoxicity against Breast Cancer Cells NK Cell Antibody-Dependent Cellular Fc-Optimized NKG2D-Fc Constructs Induce